Tianjin Medical Joint Laboratory
Tianjin First Central Hospital – University of Macau Joint Laboratory
Tianjin First Central Hospital – University of Macau Joint Laboratory brings together research on colorectal cancer liver metastasis, hepatic inflammation, and hepatocellular carcinoma, alongside TNF signaling, RNA biology, and computational analysis. The joint principal investigators are Wentao Jiang, Vinay Tergaonkar, and Zhoubo Guo.
Our work focuses on colorectal cancer liver metastasis, viral hepatitis and hepatic inflammation, and hepatocellular carcinoma. We study TNF/TNFR signaling, RNA-binding proteins, non-coding RNAs, and RNA modifications using spatial transcriptomics, spatial ATAC-seq, multi-omics, and AI-assisted analysis. Organoids, liver transplantation, and organ preservation also support this work.
Joint Research Directions
Current research directions include colorectal cancer liver metastasis; hepatic inflammation, including viral hepatitis; hepatocellular carcinoma and its transcriptional evolution; TNF/TNFR signaling and RNA-binding proteins; and patient-derived liver cancer organoids.
Principal Investigators
Wentao Jiang, MD
Vice President, Professor, Joint Principal InvestigatorTianjin First Central Hospital, Tianjin Key Laboratory of Organ TransplantationLiver transplantation, organ preservation, machine perfusion, donor graft optimization, and transplant oncology.
Vinay Tergaonkar, PhD
Chair Professor, Joint Principal InvestigatorFaculty of Medicine, University of MacauTNFR1-mediated inflammation and cell death, RNA regulation, NF-κB signaling, telomerase, and cancer biology.
Zhoubo Guo, MD
Joint Principal InvestigatorTianjin First Central Hospital, Tianjin Key Laboratory of Organ TransplantationColorectal cancer liver metastasis, hepatitis, and hepatocellular carcinoma tumor immunity.
Publications
Selected publications by the principal investigators and laboratory members are listed in the PUBLICATIONS section.
Contact / Join Us
For enquiries, contact Zhoubo Guo or Vinay Tergaonkar. Further information is available on the JOIN US page.
Tianjin First Central Hospital
Translational Research Center for Medical Devices in Organ Transplantation
Tianjin Key Laboratory of Organ Transplantation
Tianjin First Central Hospital
2 Baoshan West Road, Tianjin, China
Research center: 6 Xuefu West Road, Xiqing District, Tianjin, China
University of Macau
Faculty of Medicine
Ministry of Education Frontiers Science Center for Precision Oncology (FSCPO)
Cancer Center, Faculty of Medicine
University of Macau
E12, Avenida da Universidade, Taipa, Macao, China