RESEARCH

Joint Laboratory Research

The joint program focuses on colorectal cancer liver metastasis, hepatic inflammation including viral hepatitis, and hepatocellular carcinoma. Work on TNF/RNA regulation and computational analysis supports these areas, with transplantation and organ preservation as related research.

Colorectal Cancer Liver Metastasis

Joint research direction
Integrated high-resolution spatial transcriptomics and spatial ATAC-seq from adjacent sections of the same tissue block to examine tumor heterogeneity and interactions between CD8+ T cells and tumor cells.

Hepatic Inflammation and Viral Hepatitis

Joint research direction
Investigating TNF/TNFR signaling and the roles of non-coding RNAs, RNA-binding proteins, RNA modifications, and NF-κB in hepatic inflammation and liver cancer.

Transcriptional Characteristics and Evolutionary Trajectories of Hepatocellular Carcinoma

Joint research direction
Single-cell and spatial profiling of transcriptional states and tumor evolution.

Patient-Derived Liver Cancer Organoids

Joint research direction
Organoid models for translational studies and drug-response prediction.

Funded Research Projects

Normothermic Machine Perfusion Combined with Hypericin Alleviates Donor Liver Steatosis via the HIF-1α/SERPINE1 Axis

Tianjin Municipal Health Commission General Fund Project
2026.01–2027.12

Organ Transplantation Surgery

Tianjin Key Medical Discipline Construction Project
2025.01–2027.12

Adaptive Study of Zilongjin for the Prevention of Postoperative Recurrence and Metastasis of Liver Tumors

Special Project for High-Quality Development of Manufacturing Industry in Tianjin
2025.01–2026.12

Role and Mechanism of ASH1L in Post-Transplant Recurrence of Hepatocellular Carcinoma

Key Project of the Scientific Research Plan of Tianjin Municipal Education Commission
2024.12–2027.11

Molecular Targets and Mechanisms of Recurrence after Liver Transplantation for Unresectable Pancreatic Neuroendocrine Tumor Liver Metastases

General Project of the Scientific Research Plan of Tianjin Municipal Education Commission
2023.12–2025.11

Ex Vivo Perfusion-Based Bioactive Materials for Repairing Transplant Organ Injury and Modulating Immune Responses

Independent Research Fund, Institute of Transplant Medicine, Nankai University
2023.08–2025.07

Development of Devices and Technologies for Ex Vivo Ischemia-Free Preservation and Injury Repair of Donor Livers

Key Project of Applied Basic Research, Tianjin Science and Technology Bureau
2023.10–2026.09

Clinical Value of mTOR Inhibitors after Liver Transplantation for GEP-NET Liver Metastases

Key Discipline Special Project, Tianjin Municipal Health Commission
2022.07–2025.06

Impact of SARS-CoV-2 on the Human Cellular Ecosystem and Strategies for Infection Prevention and Control

Haihe Laboratory of Cell Ecosystem Innovation Fund
2022.01–2022.12

STYK1 Promotes Recurrence and Metastasis of Hepatocellular Carcinoma through the MEK/ERK and PI3K/AKT Signaling Pathways

Natural Science Foundation of Tianjin
2020.04–2023.04