PEOPLE
Tianjin First Central Hospital – University of Macau Joint Laboratory
Joint Principal Investigators
Wentao Jiang, MD
Vice President, Professor, Joint Principal Investigator
Tianjin First Central Hospital, Tianjin Key Laboratory of Organ Transplantation
Deputy Head, Organ Donation Group, Organ Transplantation Branch, Chinese Medical Association
Chair, Tianjin Medical Association Organ Transplantation Branch
Dr. Jiang's work spans liver transplantation, organ preservation and machine perfusion, donor graft assessment and optimization, steatotic liver grafts, and transplant oncology. His research connects clinical transplantation with experimental models to investigate graft injury, repair, and preservation.
His laboratory applies patient-derived organoids, multi-omics, spatial biology, and computational methods to liver disease and transplant-related cancer.
Academic appointments
Chair, Organ Transplantation Branch, Tianjin Medical Association
Deputy Head, Organ Donation Group, Organ Transplantation Branch, Chinese Medical Association
Vinay Tergaonkar, PhD
Chair Professor, Joint Principal Investigator
Faculty of Medicine, University of Macau
Ministry of Education Frontiers Science Center for Precision Oncology (FSCPO), University of Macau
Distinguished Principal Scientist
Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore
Adjunct Professor
Yong Loo Lin School of Medicine, National University of Singapore
Dr. Tergaonkar studies TNFR1-mediated cell death and inflammation, with particular focus on how non-coding RNAs, RNA-binding proteins, and RNA modifications regulate TNFR1 complex assembly and function. His work also examines FADD filaments and molecular mechanisms of TNF-induced apoptosis.
His broader research includes NF-κB signaling, telomerase/TERT, tumor microenvironments, cancer biomarkers, and multi-omics. In the joint laboratory, these interests connect with hepatic inflammation, hepatocellular carcinoma, and patient-derived liver cancer organoids.
Zhoubo Guo, MD
Joint Principal Investigator
Tianjin First Central Hospital, Tianjin Key Laboratory of Organ Transplantation
Dr. Guo's research includes colorectal cancer liver metastasis, hepatitis, and hepatocellular carcinoma, with a focus on tumor immunity, organoids, and bioinformatics. He previously served as an External Academic Research Scientist at The University of Chicago.
His published work includes a disulfidptosis-related lncRNA signature for predicting survival and immune response in hepatocellular carcinoma, and research on tumor-microenvironment remodeling after neoadjuvant stereotactic body radiotherapy plus immune therapy. These projects bring molecular profiling and clinical questions in liver cancer into the joint laboratory's research program.
Leadership
Jisan Sun, MD
Associate Professor
Tianjin First Central Hospital
Research focuses on liver transplantation, machine perfusion, donor organ preservation and optimization, hepatocellular carcinoma, patient-derived liver cancer organoids, and translational research.
Chiyi Chen, MD, PhD Candidate
Assistant Professor
Tianjin First Central Hospital
Research focuses on liver transplantation and transplant oncology, including hepatocellular carcinoma and neuroendocrine tumor liver metastases, patient-derived organoids, multi-omics, precision oncology, machine perfusion, and donor graft repair.
Hongyu Huang, MD, PhD Candidate
University of Macau
Nankai University
His research examines colorectal cancer liver metastasis and the tumor microenvironment, with particular interest in immunosuppressive features and interactions among tumor and immune cells. He uses spatial transcriptomics, spatial ATAC-seq, multi-omics, and machine-learning approaches, including AI-assisted analysis to characterize the tumor microenvironment.
Tianjin First Central Hospital Laboratory Members
| Name | Position |
|---|---|
| Kunning Zhang | MD Candidate |
| Wenjie Wu | MD Candidate |
| Qiming Zheng | MD Candidate |
| Zhiwei Xiong | MD Candidate |
University of Macau Research Team
| Name | Position |
|---|---|
| Yuxing Hou | PhD Student |
| Boru Wang | PhD Student |
| Tan Li | PhD Student |
| Mengyu Hong | PhD Student |
| Yi Zhou | Research Assistant |
| Shunan Hu | Research Assistant |